Week 2 contains a matchup between closing 365 days’s Offensive Rookie of the Year C.J. Stroud and the favourite to score the award this 365 days, No. 1 pick Caleb Williams.

Which young considerable particular person will seize his crew to a score?

Colin Cowherd shared his approved picks for Week 2, including that showdown between Stroud’s Texans and Williams’ Bears, and the mountainous matchup on FOX between the Saints and the Cowboys.

(All times ET)

49ers @ Vikings (+5)
1 p.m., CBS

Colin’s pick, accumulate prediction: Vikings +5 (49ers score, 26-23)

Colin’s tips: “Niners are on a short week. … Christian McCaffrey is still out. Sam Darnold is playing his old team. He’s faced them in practice. I think they [Vikings] put some pressure. … I think this goes down to the final sequence, the final minutes of the game.”

Saints @ Cowboys (-6)
1 p.m., FOX and FOX Sports app

Colin’s pick, accumulate prediction: Cowboys -6 (Cowboys score, 30-20)

Colin’s tips: “When Dak Prescott and Mike McCarthy are favored and playing an inferior team, they roll them. They’re very comfortable as a favorite, playing downhill. The Saints were 1-5 against playoff teams last year. The Saints get their wins off lousy teams.”

Jets @ Titans (+3.5)
1 p.m., CBS

Colin’s pick, accumulate prediction: Jets -3.5 (Jets score, 24-10)

Colin’s tips: “The Jets offense is gonna get better every week. … And I’m not sure Tennessee has an NFL quarterback. The Jets were humiliated physically. They’ll play with their hair on fire. Their defense will be fine.”

Steelers @ Broncos (+2.5)
4:25 p.m, CBS

Colin’s pick, accumulate prediction: Broncos +2.5 (Broncos score, 23-20)

Colin’s tips: “I think Sean Payton and his guys … they may not have great personnel, but they held the Seahawks to 158 passing yards and got two turnovers. I’ve said all offseason: I think Denver’s personnel is better than you think.”

Blazin’ 5: Vikings cowl vs. 49ers, Jets beat Titans, Texans over Bears NFL Blazin’ 5: Vikings cover vs. 49ers, Jets beat Titans, Texans over Bears

Bears @ Texans (-6.5)
8:20 p.m., NBC

Colin’s pick, accumulate prediction: Texans -6.5 (Texans score 27-17)

Colin’s tips: “I think C.J. Stroud is incredible. The kid’s unbelievable. He’s intentional with his running, he’s one of the more accurate passers. Now they’ve given him Joe Mixon … they’ve added Stefon Diggs. And by the way, the Bears offense is a mess. I think Houston is gonna totally dominate time of possession. I think it’s a mismatch, and I don’t get the line.”

Need immense tales delivered accurate to your inbox? Device or log in to your FOX Sports legend, and note leagues, teams and players to fetch a personalized e-newsletter day-to-day!

NFL National Football League

Get extra from National Football League Follow your favorites to accumulate records about games, news and additional

Source: Fox Sports

Copyright GambleCompare.net 2026. 21+ Please gamble responsibly! Terms and Conditions Apply. Gambling Problem? Call 1-800-GAMBLER Gambling involves risk. Please gamble responsibly. Gambling laws and age restrictions vary by state. Offers and operators displayed on this website may not be available in all jurisdictions. This website contains affiliate links. We may receive compensation if you click a link and/or sign up with one of our partners. Online Wagering is illegal in some states. GambleCompare takes no responsibility for your actions. It is your responsibility to check your local regulations before playing online.